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Thursday, August 8, 2013
Malaria vaccine shows early promise in clinical trials
By Rebecca Morelle
A malaria vaccine has shown promising results in early stage clinical trials, according to researchers.
Researchers found the vaccine, which is being developed in the US, protected 12 out of 15 patients from the disease, when given in high doses.
The method is unusual because it involves injecting live but weakened malaria-causing parasites directly into patients to trigger immunity.
The research is published in the journal Science.
Lead author Dr Robert Seder, from the Vaccine Research Center at the National Institutes of Health, in Maryland, said: "We were excited and thrilled by the result, but it is important that we repeat it, extend it and do it in larger numbers."
Many bites
It has been known for several decades that exposure to mosquitoes treated with radiation can protect against malaria.
However, studies have shown that it takes more than 1,000 bites from the insects over time to build up a high level of immunity, making it an impractical method of widespread protection.
Instead, a US biotech company called Sanaria has taken lab-grown mosquitoes, irradiated them and then extracted the malaria-causing parasite (Plasmodium falciparum), all under the sterile conditions.
These living but weakened parasites are then counted and placed in vials, where they can then be injected directly into a patient's bloodstream. This vaccine candidate is called PfSPZ.
To carry out the Phase-1 clinical trial, the researchers looked at a group of 57 volunteers, none of whom had had malaria before.
Of these, 40 received different doses of the vaccine, while 17 did not. They were then all exposed to the malaria-carrying mosquitoes.
The researchers found that for the participants not given any vaccine, and those given low doses, almost all became infected with malaria.
However for the small group given the highest dosage, only three of the 15 patients became infected after exposure to malaria.
Dr Robert Seder said: "Based on the history, we knew dose was important because you needed 1,000 mosquito bites to get protection - this validates that.
"It allows us in future studies to increase the dose and alter the schedule of the vaccine to further optimise it. The next critical questions will be whether the vaccine is durable over a long period of time and can the vaccine protect against other strains of malaria."
He added that the fact that the vaccine had to be injected into the bloodstream rather than into or under the skin made delivery more difficult.
Commenting on the research, Dr Ashley Birkett, from the Path Malaria Vaccine Initiative, said: "They are clearly very early stage trials in small numbers of volunteers, but without question we are extremely encouraged by the results."
He added that most current vaccine candidates targeted parts of the P. falciparum parasite rather than the whole organism.
"This approach induces a broad response against a lot of different targets on the parasite," he said.
There are currently about 20 malaria vaccine candidates in clinical trials.
The most advanced is called RTS,S/AS01, which has been developed by the pharmaceutical company GlaxoSmithKline, and is in a Phase-3 clinical trial involving 15,000 children in Africa.
According to the latest figures from the World Health Organization, there were an estimated 219 million cases of malaria in 2010 and an estimated 660,000 deaths.
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President Zardari urges nation to share Eid festivitiy with victims of terrorism, sectarianism
PPP Social Media CellPresident Asif Ali Zardari Thursday felicitated the nation on Eid-ul-Fitr and urged the people to feel and share the pains of the victims of terrorism and sectarianism on the festive occasion. The President in a message said “we must not forget the pains of those brothers and sisters who have fallen a victim to terrorism.” “Lets also share our joys with those who have suffered at the cost of sectarianism,” President Zardari said. The President exhorted the nation, not (not) to put aside at any cost the spirit of mutual affinity, sharing of pain, tolerance, respect for humanity and well being of others.“We should also try to completely eradicate sectarianism and intolerance,” he said. The President felicitated all countrymen on the festive occasion of Eid ul Fitr and prayed that may this eid prove to be a source of abundant joy for all. He said the occasion this year comes at a time, when the nation has achieved a milestone in its journey towards democracy. He said a new democratic era has dawned after the completion of a term of a government. The President said the completion of democratic transition was an important achievement of the nation and it deserves to be felicitated on both these counts. “Lets bow our heads before Allah Almighty on this blessed and joyous occasion and offer our gratitude for granting us the gift of Eid ul Fitr.” The President asked the nation to share the happiness of Eid with families, friends, neighbours and those deserving people, who due to some reason were unable to fully enjoy the festivity. He said “we must resolve to share our happiness with the needy, deserving, poor and the deprived, and to carry forward this tradition.” “I pray to Allah Almighty that he protects us all with His benevolence and showers His blessings on us and makes this country a centre of peace and security. Aameen,” President Zardari said.
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Bahrain Bans Protests: Human Rights Activist Says 'Physical, Psychological, Sexual' Torture Continues
Bahrain human rights activist Maryam Al-Khawaja says the government there is escalating its crackdown on protests in advance of a major opposition rally, and says that the regime continues to torture detainees. Al-Khawaja, President of The Bahrain Center For Human Rights, appeared on HuffPost Live Wednesday to discuss the Bahraini government's ban on protests as well as the cases of a photojournalist and blogger who were arrested and abused by police with host Ahmed Shihab-Eldin.
King Hamad's royal decree last week banned protests in the country's capital, Manama, and heightened "punishments" for those citizens who do not abide by the decree. The decree comes just two weeks before a major opposition rally planned for August 14, the celebration of Bahrain's independence from the United Kingdom. While the Bahraini government has framed the decree as an amendment to the 2006 Law on the Protection of Society from Acts of Terrorism, the United Nations has expressed concern over what exactly this entails. In addition to the revocation of citizenship for anyone found guilty of terrorism and an increased detention period, it also bans sit-ins, rallies, and gatherings in the capital.
Al-Khawaja told HuffPost Live that the decree merely legalizes practices that have been in place for years, and the government has begun increasing its crackdown on protestors in recent weeks.
"Basically they're in a sense legalizing things that they've already been doing. Whether we're talking about the revoking of citizenship, or the forbidding of protests within Manama -- this all something that's been in practice for a while now," she said. "What we've been seeing in the past couple weeks since the announcing of the planned protest on the 14th of August ... [is] a very severe escalation in the crackdown. Usually what we see is house raids and arrests during the night. But in the past couple weeks we've been seeing them throughout the day. We haven't even been able to keep up with the numbers on the amount of people being arrested and the amount of homes being raided on a daily basis."
With the arrests mounting, Al-Khawaja noted that often people are arrested without the opportunity to consult with a lawyer.
"In Bahrain people are taken to the the prosecution without the presence of a lawyer," she said, claiming that the government has reportedly implemented the new practice of taking those arrested to public prosecution at odd hours of the night when lawyers are typically unavailable. This was the case, she said, with recently arrested photojournalist Hussain Hubail.
She added that blogger Mohammed Hasan was arrested and abused by police. His attorney reported "visible marks of beating on his arms," and Al-Khawaja said that there were marks of torture on his back and lower abdomen as well.
"The majority of cases of people that we document who have been arrested have either been beaten and/ or tortured. It ranges ... from physical, to psychological, to sexual," said Al-Khawaja.
President al-Assad performs Eid al-Fitr Prayer at Anas Bin Malek Mosque in Damascus
http://sana.sy/index_eng.htmlPresident Bashar al-Assad performed Thursday the Prayer of Eid al-Fitr (Feast of Breaking the Fast) at Anas Bin Malek Mosque in Damascus with the participation of senior officials in the state and the Baath Arab Socialist Party (BASP), a number of the People's Assembly members, Syria's Grand Mufti, several Islamic scholars and a crowd of citizens. Upon his arrival at the Mosque, President al-Assad was received by Minister of Awqaf (Religious Endowments), the Mufti, the BASP Assistant Regional Secretary, the People's Assembly Speaker and the Prime Minister. Following the prayers which were led by Imam Ahmad al-Jazaeri, the President listened to the Eid sermon with sheikh al-Jazaeri, stressing the sublime meanings of Eid al-Fitr and the importance of love, fraternity and unity among the homeland's people. "Islam unifies the Ummah (the Islamic nation) rather than dividing it, strengthens it rather than weakening it," said Sheikh al-Jazaeri, affirming that the Islamic religion fights bigotry and denounces takfiri thinking and violence. He asked God to dispel the crisis facing Syria so as for security and safety to be restored to it and for smile to be redrawn on the children's faces on al-Eid. Sheikh al-Jazaeri underscored that Bilad al-Sham has always been the country of knowledge, faith and purity, stressing that the reform of the homeland and the Islamic nation lies in the correct understanding of Quran which shows clearly that Islam is a religion of tolerance and mercy and not of killing and violence. Al-Jazaeri concluding his sermon by asking God to stand by President al-Assad for the welfare of the homeland and the citizens and to have mercy upon Syria and its people.
Meanwhile, Syrian Information Minister Omran al-Zoabi denied reports suggesting that Assad’s motorcade had come under attack while he was on his way to the mosque. “These reports are totally false. The president was driving his car himself, he attended the prayer and greeted people… everything is normal,” the minister stated. Syria has been gripped by deadly unrest since 2011. Clashes between foreign-backed Takfiri militants and the Syrian army continue on a daily basis.
PAKISTAN: Stop Merger of Ministry of Human Rights with Ministry of Law & Justice
The Asian Human Rights Commission (AHRC) has received information that the government of Pakistan has merged the Ministry of Human Rights (MoHR) with the Ministry of Law and Justice (MoLJ) on June 7, allegedly to pursue its policy of denying people their fundamental rights under the constitution. The government’s decision will result in Parliament not being able to closely monitor human rights issues. This will undermine the importance of human rights and human rights violations in the country. It is not the first time that Prime Minister Nawaz Sharif has abolished the ministry of human rights as an independent entity. When he came in power in 1997, he did the exact same thing with the MoHR, due to his political rivalry with former Prime Minister Benazir Butto. Benazir Butto had, during her first tenure in 1988, also formed a Human Rights Cell in the Prime Minister Secretariat. This too was abolished in 1990 Prime Minister Nawaz Sharif. History repeats itself now with Nawaz Sharif again deciding to abolish the MoHR, recreated in 2008 by the previous government of Pakistan People’s Party. The incumbent government has also lifted the moratorium on death sentences, which had remained in force for the past five years. Please sign the urgent appeal and urge international human rights organizations, including the UN, to use their influence on the present government so it may restore the Ministry of Human Rights as an independent entity and abolish the death sentences.After the merger of the Human Rights Ministry, there would only be one minister dealing with law and legal affairs, matters related to the justice system, and all issues pertaining to human rights and survivors of HR abuses. In other words, affairs related to human rights will most likely become a third priority for the minister in-charge. Difference between the mandates of the Ministry of law and the Ministry of human rights is inconceivable for the government under Prime Minister Nawaz Sharif. The mandate of the Ministry of law and justice is to defend laws and represent the state in courts on all matters including those pertaining to human rights violations by the state. On the other hand, the mandate of the Ministry of human rights is to redress the grievances of the survivors/victims and to protect and safeguard the rights of the people and their interests. The merger decision will also affect the rights of women. The subject of Women’s Development had been retained federally under the Ministry of human rights and now women issues will lose priority and focus. The same will be the case with the rights of children, youth, and religious minority groups, which will all be undermined. The ill-intentions of the incumbent government against human rights can be judged by its lifting the moratorium on death sentences and starting the process of hanging prisoners on death row. The previous government of the Pakistan People’s Party had suspended executions during its tenure that expired on June 30 this year. The government has not consulted other political parties in taking its decision to proceed with executing death sentences. Further undoing undo steps taken by the last government towards reform, the government of Nawaz Sharif has suspended the process that was leading to the formation of a National Human Rights Commission (NCHR) supposed to be established in accord with an act of Parliament passed in May 2012. The MoHR had been working on drafting legislation on custodial torture and rehabilitation of torture survivors . It had almost completed consultations with civil society. After the merger, legislation against torture will be put on the back burner. Read More: http://www.humanrights.asia/news/urgent-appeals/AHRC-UAG-003-2013
Pakistan: Fighting terrorism
The executive summary of the Nacta draft for a counterterrorism policy seems to gravitate around a singular state narrative — that terrorism in Pakistan is linked with the Afghan war of the 1980s and continues due to foreign intervention. Moreover, the source of all violence is North Waziristan, and by association, Afghanistan. Such a diagnosis creates problems in comprehending the issue in its entirety. Many people erroneously believe in such theses, resulting in the conclusion that the withdrawal of the US will automatically bring peace in the region. Notwithstanding the fact that America’s invasion was a costly blunder, the US withdrawal at this quick pace will not be sufficient to deal with terrorism. Following are the reasons which establish that the menace of terrorism will not be addressed with the above perspective in mind. First, such an explanation doesn’t help in taking into account the manner in which sources of terrorism have expanded in the country. The foreign intervention next door may be a driver of terrorism in the tribal areas and the Pashtun-belt in general, but this framework certainly does not explain what is happening in the rest of Pakistan. Second, an overemphasis on America’s involvement in creating jihadis in South Asia, not taking cognisance of the past or present links of the military with militant organisations, does not help in understanding the penetration of these outfits within the security and law-enforcement establishments, and the government in general. There is no doubt that militancy, as a menace, dates back to the 1980s when the Zia regime willingly allowed radicalisation of society in order to fight the American war against the Soviet troops. However, we cannot deny the fact that our security establishment held on to these jihadis, which were used on other fronts. Third, such a connection has compelled the military and state in general to turn a blind eye to sectarian violence, which is considered as an unpleasant consequence of the jihadi agenda that is tolerated because of the efficacy of the jihadis in countering the external threat or the internal threat in the form of Baloch and Sindhi nationalism. These groups create political and diplomatic space for the state. Their services will be critical after the foreign troops withdraw from Afghanistan in 2014. Fourth, the problem with the Afghanistan-centric narrative is that it is limited to dealing with criminal-cum-ideological gangs like Hakimullah Mehsud’s TTP but not with much larger problems in the form of Punjab-based militant networks. The popular narrative constructed and spread is that every terrorist activity, taking place in Punjab, is controlled from North Waziristan, which tends to take attention away from the expansionist designs and the rabid ideology of the Salafi and Deobandi groups ensconced in the largest province. This is also an excuse to focus on North Waziristan because the level of violence in the rest of the country, especially Punjab and Sindh, is not proportional to the jihadi presence there. The Punjab model of jihadism and extremism is different from that of Fata as these groups carefully engage society to avoid attracting attention. This makes it look like as if the problem has come from somewhere else. But if we begin to look at their literature, we will be able to see that they are much more expansionist and cunning in their tactics than those in the tribal areas, who are exposed due to their violence. In fact, violence as a measure of extremism is problematic as it fails to capture the extent of radicalisation of the society. Violence can be described as the tip of the iceberg of radicalism that is difficult to measure, especially when people continue to confuse radicalism with conservatism, which, in turn, is owned as part of the local culture. Sectarian violence is one of the examples of how the culture argument is used to downplay this crime. Surely, there were always sectarian differences but not the kind of violence that we see today. Therefore, any problem-solving will have to, on the parallel, deal with countering radicalism. This is, indeed, an issue that is gently broached in the Nacta draft policy. However, this is also a Herculean task, which no one has a clue about how to undertake this at the moment. Fifth, due to our limited analysis, we are unable to see that the jihadi leadership of the Salafi and Deobandi groups is middle class and thus much more capable of expanding their message and membership. The militant outfits in Punjab and Sindh do not just operate as groups but as a network, which has means to penetrate the society through welfare outfits and madrassas, and also influence policies through political partnerships. For instance, the JUI-F is a formidable umbrella for the expansion of militancy in Sindh. The Deobandi Tableeghi Jamaat must also be reviewed in the role it has played in expanding a particular mindset and ideology. In one particular case of an attack on the Ahmadi community in Lahore, the attackers allegedly stayed at the Tableeghi Jamaat’s centre. We also fail to see the growing trends of radicalism and radical movements in non-Pashtun Pakistan that takes various shapes and forms. For instance, while the various Deobandi and Salafi networks infiltrate society selectively at the levels of the lower and middle class in general, there are other forms like the Hizbut Tehrir (HuT), which do not necessarily encourage violence but have managed to penetrate the upper-middle class and succeeded in convincing its members to support the establishment of a khilafa and a sharia-based system in the country. This is easier said than done, especially when there are ideological differences within the religious discourse. The risk is that the khilafa formula will create more chaos and violence. More important, all these groups with differing agendas converge at the same point. This is not to undermine the argument that there may be foreign intervention. However, how can the state tell the difference between local versus foreign-sponsored if it allows jihadism, be it friendly or unfriendly? No security establishment has a master switch with which it can ensure that those who join the friendly militants will not become unfriendly tomorrow.
Pakistani Army Accused Of Killing Indian Soldiers In Ambush
Radio Free Europe/Radio LibertyFor the first time, India has openly accused the Pakistani army of being directly involved in an ambush that killed five Indian soldiers. India's Defense Minister A.K. Antony told parliament on August 8 that it was clear that Pakistani "specialist troops" were behind the attack on an army patrol in Indian-administered Kashmir on August 6. Antony indicated that the attack would harm the country's bilateral relations and warned of possible military retaliation. "Our restraint should not be taken for granted, nor should the capacity of our armed forces and resolve of the government to uphold the sanctity of the Line of Control ever be doubted," he said Antony was referring to the de facto border dividing Kashmir, which Islamabad and New Delhi both claim and have fought two wars over. Pakistan has denied any involvement in the attack.
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Eidi for the jailed: President Zardari grants special remission in sentences to prisoners
The Express TribunePresident Asif Ali Zardari, on the advice of the Prime Minister, has granted a special remission in sentences to convicts of different categories on the occasion of forthcoming Eid-ul-Fitr 2013. A special remission of 90 days has been granted to prisoners sentenced to life in prison, except to those prisoners convicted for heinous crimes including murder, espionage and anti-state activities, sectarianism, rape, robbery, abduction and terror acts. A special remission for 45 days has also been granted to all other convicts except condemned prisoners and those convicted of heinous crimes and those undergoing sentences under the Foreigners Act 1946. The remissions will be applicable on only those prisoners who have served two-thirds of their substantive sentences. Total remission has been granted to male prisoners who are 65 years of age or above and female prisoners who are 60 years of age or above who have undergone at least a third of their substantive sentence of imprisonment, except those involved in culpable homicide and those involved in terror acts. A special remission of one year has also been allowed for female prisoners who have accompanying children and are serving sentences for crimes other than culpable homicide and terrorism. Juvenile convicts who have served a third of their substantive sentence can enjoy total remission if they were not involved in culpable homicide, terrorist act, rape, robbery, dacoity, kidnapping or abduction or anti-state activities.
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Balochistan plunges into darkness
Daily TimesBalochistan’s 17 districts plunged into darkness once again when heavy storms damaged the recently repaired 220kV towers of circuit transmission line in the night between Tuesday and Wednesday. According to the details released by Quetta Electric Supply Company (QESCO), two towers of 220kV were damaged in the Aabgum area of Bolan in the heavy floods on the night between Tuesday and Wednesday, cutting supply of electricity to 17 districts of the province. Officials said supply was soon restored to the capital city Quetta from private powerhouses. They added that the other district headquarters of the province would only get one hour of electricity. They said that only 120MW of electricity was available for the 17 districts which will consequently result in longer hours of load shedding. The QESCO officials also conveyed an official apology to the people for delayed start of repair work on damaged towers due to security clearance. It may be recalled here that four towers, two each of 132kV and 220kV, were blown up on August 5 in Bolan, heavily damaging the transmission lines. The recent storm two of them again.
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